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Febrile Neutropenia

Axel Glasmacher
Chris Kibbler
Archie Prentice

November 2006




ISBN 978-1-85315-682-3

Febrile Neutropenia

The term 'febrile neutropenia' concerns the infections to which patients receiving chemotherapy are susceptible once anti-cancer drugs have suppressed their bone marrow.

This book contains three introductory chapters from the three conference co-chairmen, followed by five workshops on particular problems: oral antibiotic treatment, the choice of antibiotic for single-agent therapy, bacterial resistance and two specific types of infection, those that affect the central venous line used for drug delivery and pneumonia (a common cause of death). A crucial feature of the original conference was the high-quality debates that followed each presentation, and the book preserves their flavour at the end of each chapter. Key points emerging from the workshops are summarised in the text, and suggested guidelines are presented.

This book provides a crash course for those unaccustomed to the field and a valuable pointer to rational therapy for those who deal with the syndrome of febrile neutropenia on a day-to-day basis.


Robin Williamson

Axel Glasmacher

Bacterial infections in neutropenic patients: definition of the clinical
Archie Prentice

Bacterial resistance: driver and consequence of antibiotic
Chris Kibbler

Treatment recommendations and guidelines for febrile
neutropenia: methodological and clinical observations
Axel Glasmacher

Workshop 1: Oral antibiotic therapy in low-risk patients
Marie von Lilienfeld-Toal, David Linch, Markus Ruhnke,
Miguel Sanz (moderator)

Workshop 2: Drug choice in antibiotic monotherapy
Mickael Aoun (moderator), Emilio Bouza, Gordon Cook, Axel Glasmacher,
Jean-Pierre Marie

Workshop 3: Bacterial resistance
Murat Akova, Chris Kibbler, Cornelia Lass-Floerl, Francesco Menichetti, Paul
Verweij (moderator)

Workshop 4: Central venous line infections
Mickael Aoun, Emilio Bouza (moderator), Gordon Cook, Cornelia Lass-
Floerl, Francesco Menichetti, Archie Prentice

Workshop 5: Pneumonia
Murat Akova, Axel Glasmacher, Chris Kibbler, David Linch, Jean-Pierre
Marie, Markus Ruhnke (moderator), Paul Verweij

General Medicine

Round Table Series

Axel Glasmacher/Chris Kibbler/Archie Prentice